Evan C. Unger, MD

Professor Emeritus, Medical Imaging - (Research Scholar Track)
Professor Emeritus, Biomedical Engineering

Dr. Unger is Professor Emeritus of Medical Imaging and Biomedical Engineering at the University of Arizona. He received his medical degree from University of California at San Francisco School of Medicine. He completed his early training in Radiology at Mallinckrodt Institute of Radiology in St. Louis, MO. He has been an innovator in a number of fields and is inventor on more than 112 issued US patents. He has extensive experience in clinical translation. Research SupportPrincipal Investigator, NIH STTR, 1R41NS057860-01A-1, Targeted Blood Brain Barrier Permeability Changes with Ultrasound and Microbubbles, $949,596.00 in total funding, Sept. 1st 2007 to August 31st, 2009.PI of subcontract, NIH I Rol EBoo9o50-oi, Ultrasound and Targeted Microbubbles to Treat Myocardial Infarction, PI Xie, $201,600 in funding to my lab in sub-contract 2008 to 2013. My lab makes non-targeted bubbles and bubbles targeted to GPIIBIIIA and to fibrin for the project.Co-investigator, "Microbubble Enhanced FUS for More Efficient Therapy of Uterine Fibroids," $102,324.00 received from FUS Foundation, April 2009 to April 2010.Principal Investigator, "Development of Novel Sensitizer to Improve Response of Hypoxic Tumors to Radiation," 1R43CA144817-oi, $204,000, 7/01/2010 to 12/31/2010.Program Co-Leader, Arizona Cancer Center Imaging Program, NCI P50, January 2010 to present provides about io% of my salary support from NCI.Co-investigator, "Biological nanocomposites (BNC) to diagnose diabetic pre-retinopathy." QTDP program, stimulus funds from federal government through IRS. $488,000.00, July 1st 2010 to December 31st, 2010. My lab does the bulk of the work on this project preparing the nanoparticles and targeting ligands for theranostic targeted to e-Selectin in diabetic pre-retinopathy. 

Degrees
  • MD: University of California, San Francisco - 1982
Honors and Awards
  • Editor’s Honoree for Laboratory Investigation, Journal of Vascular Interventional Radiology, “Dodecafluropentane emulsion decreases infarct volume in a rabbit ischcmic stroke model, 2013
  • Innovator of the Year, University of Arizona (top faculty innovator in entire university), 2011
  • Present Consultant to the Editor for Radiology, 2011
  • Associate Editor of Radiology, 2002-2011
  • American College of Radiology, 2002 Fellow
  • Radiology Editor's Recognition Award for reviewing with Special Distinction, 2001
  • Radiology Editor's Recognition Award for reviewing with Distinction, 1999 & 2000
Internship
  • University of Colorado, Internal Medicine, 1982-1983
Residency
  • Washington University, Diagnostic Radiology, 1983-1986
Board Certifications
  • American Board of Radiology, 1986

Select Publications

2019

Lickliter, J., J. Ruben, R. Carmody, and J. Becker et al, A phase ib/ii clinical trial of dodecafluoropentane emulsion (ddfpe) as a radiosensitizer in glioblastoma, 2019.
Liu, Z., C. Barber, A. Gupta, L. Wan, Y-W. Won, L. R. Furenlid, Q. Chen, A. A. Desai, M. Zhao, D. A. Bull, et al., "Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction.", Nucl Med Biol, vol. 70, pp. 67-77, 2019 03. PMCID: PMC6778684  PMID: 30772168

2018

Weinkauf, C. C., K. Concha-Moore, J. R. Lindner, E. R. Marinelli, K. P. Hadinger, S. Bhattacharjee, S. S. Berman, K. Goshima, L. R. Leon, T. O. Matsunaga, et al., "Endothelial vascular cell adhesion molecule 1 is a marker for high-risk carotid plaques and target for ultrasound molecular imaging.", J Vasc Surg, vol. 68, issue 6S, pp. 105S-113S, 2018 12. PMCID: PMC6089675  PMID: 29452833

2011

Roach, M., J-L. Alberini, A. Paul Pecking, A. Testori, F. Verrecchia, J. Soteldo, U. Ganswindt, J. L. Joyal, J. W. Babich, R. S. Witte, et al., "Diagnostic and therapeutic imaging for cancer: therapeutic considerations and future directions.", J Surg Oncol, vol. 103, issue 6, pp. 587-601, 2011 May 1.