Srinivasan Vedantham, PhD, DABR, FAAPM

Professor, Medical Imaging
Associate Director of Biomedical Imaging Innovation / Clinical Translation in Next-Gen CT
Director of the Office for Project Statistical and Design Support

Srinivasan Vedantham, PhD, DABR, FAAPM, is a Professor in the Department of Medical Imaging.  He joined the University of Arizona after serving as a faculty at the Department of Radiology at the University of Massachusetts Medical School and as an adjunct faculty in Biomedical Engineering at Worcester Polytechnic Institute.  He received his PhD in Biomedical Engineering from Worcester Polytechnic Institute, Worcester, MA, and subsequently joined as a faculty at the Department of Radiology at Emory University School of Medicine, Atlanta, GA.

Dr. Vedantham has received numerous honors and awards.  He received the Cancer Research Award from the Georgia Cancer Coalition and the Dr. Karen Mudry Award from the Institute of Biomedical Engineering Research (IBER).  He contributed to the article that received the Farrington Daniels Award for the best paper in radiation dosimetry in Medical Physics Journal and the article that was selected as Editor’s Choice in Basic Science in the Journal of Neurointerventional Surgery. 

Dr. Vedantham is a member of several professional organizations: The American Association of Physicists in Medicine (AAPM), the Institute of Electrical and Electronics Engineers (IEEE), and the International Society for Optics and Photonics (SPIE).  He was elected as Fellow by the American Association of Physicists in Medicine (AAPM).   

Several of Dr. Vedantham’s publications can be found at:

Research Interests: 

Dr. Vedantham’s research interests are in the design, development and clinical translation of novel x-ray imaging systems and imaging techniques with particular focus on oncological and interventional imaging.  He along with his collaborators and colleagues had made major contributions to breast cancer imaging including small-field digital mammography for stereotactic core-biopsies, full-field digital mammography and digital breast tomosynthesis.  Currently, he is working on developing advanced tomographic techniques and systems for breast imaging and its clinical translation.  This design, development and clinical translation oriented research is funded by the National Institutes of Health.  He is also conducting research in interventional imaging with a focus on the development of advanced detector technology.  

  • PhD: Worcester Polytechnic Institute, 2002
  • MS: The University of Akron, 1997
  • BE (Honors): Birla Institute of Technology & Science, Pilani, India, 1992
Honors and Awards
  • Elected Fellow, American Association of Physicists in Medicine, 2016
  • Editor’s Choice in Basic Science, Journal of Neurointerventional Surgery, 2015
  • Farrington Daniels Award, American Association of Physicists in Medicine, 2008
  • Best Diagnostic Paper, Southeastern Chapter of the American Association of Physicists in Medicine, 2008
  • Cancer Research Award, Georgia Cancer Coalition, 2006
  • Dr. Karen Mudry Award, Institute of Biomedical Engineering Research, 1997

Select Publications


Vedantham, S., H. Wu Tseng, S. Konate, L. Shi, and A. Karellas, "Dedicated cone-beam breast CT using laterally-shifted detector geometry: Quantitative analysis of feasibility for clinical translation", Journal of X-Ray Science and Technology,, 04/2020.
Tseng, H. Wu, S. Vedantham, and A. Karellas, "Cone-beam breast computed tomography using ultra-fast image reconstruction with constrained, total-variation minimization for suppression of artifacts", Physica Medica, vol. 73, 05/2020.


Tseng, H. W., S. Vedantham, S. H. Cho, and A. Karellas, "Joint optimization of collimator and reconstruction parameters in x-ray fluorescence computed tomography using analytical point spread function and model observer.", IEEE Trans Biomed Eng, 2019 Dec 30. PMID: 31899411


Sujlana, P. S., M. Mahesh, S. Vedantham, S. C. Harvey, L. A. Mullen, and R. W. Woods, "Digital breast tomosynthesis: Image acquisition principles and artifacts.", Clin Imaging, 2018 Sep 13.
Vedantham, S., and A. Karellas, "Emerging Breast Imaging Technologies on the Horizon.", Semin Ultrasound CT MR, vol. 39, issue 1, pp. 114-121, 2018 Feb. PMCID: PMC5773258  PMID: 29317033
Arif-Tiwari, H., C. O. Twiss, F. C. Lin, J. T. Funk, S. Vedantham, D. R. Martin, and B. T. Kalb, "Improved Detection of Pelvic Organ Prolapse: Comparative Utility of Defecography Phase Sequence to Nondefecography Valsalva Maneuvers in Dynamic Pelvic Floor Magnetic Resonance Imaging.", Curr Probl Diagn Radiol, 2018 Aug 23.
Shi, L., S. Vedantham, A. Karellas, and L. Zhu, "The role of off-focus radiation in scatter correction for dedicated cone beam breast CT.", Med Phys, vol. 45, issue 1, pp. 191-201, 2018 Jan. PMCID: PMC5985236  PMID: 29159941
Vijayaraghavan, G. R., S. Vedantham, G. Santos-Nunez, and R. Hultman, "Unifocal Invasive Lobular Carcinoma: Tumor Size Concordance Between Preoperative Ultrasound Imaging and Postoperative Pathology.", Clin Breast Cancer, 2018 Jul 27. PMID: 30131246
Li, Z., A. Bilgin, K. Johnson, J-P. Galons, S. Vedantham, D. R. Martin, and M. I. Altbach, "Rapid High-Resolution T Mapping Using a Highly Accelerated Radial Steady-state Free-precession Technique.", J Magn Reson Imaging, 2018 Aug 24.
O'Connell, A. M., A. Karellas, S. Vedantham, and D. T. Kawakyu-O'Connor, "Newer Technologies in Breast Cancer Imaging: Dedicated Cone-Beam Breast Computed Tomography.", Semin Ultrasound CT MR, vol. 39, issue 1, pp. 106-113, 2018 Feb. PMCID: PMC5957539  PMID: 29317032


Shi, L., S. Vedantham, A. Karellas, and L. Zhu, "X-ray scatter correction for dedicated cone beam breast CT using a forward-projection model.", Med Phys, vol. 44, issue 6, pp. 2312-2320, 2017 Jun.
Ulano, A. C., S. Vedantham, and D. Takhtani, "Revisiting the indirect signs of a temporal bone fracture: air, air, everywhere.", Emerg Radiol, 2017 Apr 03.
Vijayaraghavan, G. R., S. Vedantham, M. Kataoka, C. DeBenedectis, and R. M. Quinlan, "The Relevance of Ultrasound Imaging of Suspicious Axillary Lymph Nodes and Fine-needle Aspiration Biopsy in the Post-ACOSOG Z11 Era in Early Breast Cancer.", Acad Radiol, vol. 24, issue 3, pp. 308-315, 2017 Mar. PMCID: PMC5309157  PMID: 27916595
Marosfoi, M., F. Clarencon, E. T. Langan, R. M. King, O. W. Brooks, T. Tamura, J. M. Wainwright, M. J. Gounis, S. Vedantham, and A. S. Puri, "Acute thrombus formation on phosphorilcholine surface modified flow diverters.", J Neurointerv Surg, 2017 Jul 08.
Shrestha, S., S. Vedantham, and A. Karellas, "Towards standardization of x-ray beam filters in digital mammography and digital breast tomosynthesis: Monte Carlo simulations and analytical modelling.", Phys Med Biol, vol. 62, issue 5, pp. 1969-1993, 2017 Mar 07. PMCID: PMC5384796  PMID: 28075335