Mark "Marty" Pagel, PhD

Professor, Radiology
Professor, Biomedical Engineering
Professor, Chemistry and Biochemistry
Professor, BIO5 Institute
Director, Contrast Agent Molecular Engineering Laboratory

Dr. Mark "Marty" Pagel joined the University of Arizona in 2008. He previously conducted research into the use of MRI methods to evaluate anti-cancer research at Pharmacia Corp. and Case Western Reserve University. Dr. Pagel's chemistry laboratory, located in the Arizona Cancer Center, provides an outstanding environment for cancer imaging research.  Dr. Pagel has continued to apply MRI methods to evaluate anti-cancer therapies, and has developed a new type of MRI contrast agent for in vivo studies of mouse models with cancer.  Dr. Pagel has also expanded his research program to develop contrast agents and methods for optical imaging and photoacoustic imaging.  His interdisciplinary research with molecular imaging contrast agents facilitates many collaborations between biomedical imaging and cancer biology researchers. Awards & Honors 2010, Sydney E. Salmon Distinguished Junior Investigator Award, Arizona Cancer Center, Tucson, AZ 2006, Case School of Engineering Graduate Teaching Award, CWRU, Cleveland, OH 2006, J. Bruce Jackson, M.D. Award nomination for Excellence in Undergraduate Mentoring, Case Western Reserve University, Cleveland OH 2005, J. Bruce Jackson, M.D. Award nomination for Excellence in Undergraduate Mentoring, Case Western Reserve University, Cleveland OH 2005, Carl F. Wittke Award nomination for Excellence in Undergraduate Teaching, Case Western Reserve University, Cleveland, OH 2005, Young Investigator Award, Contrast Media Research 2005 Symposium 1994, Staff Award, Department of Chemistry, Indiana University 1988, John C. Sowden Memorial Prize, Department of Chemistry, Washington University Education PhD: University of California, Berkeley CA, 2003 - Chemistry Undergraduate: Washington University, St. Louis MO, 1988 - Chemistry, Biology

Research Interests: 

Molecular Imaging

Select Publications

2016

Yoshimaru, E. S., E. A. Randtke, M. D. Pagel, and J. Cárdenas-Rodríguez, "Design and optimization of pulsed Chemical Exchange Saturation Transfer MRI using a multiobjective genetic algorithm.", J Magn Reson, vol. 263, pp. 184-92, 2016 Feb.
Type of Publication: Journal Article

2015

Chen, L. Qi, E. A. Randtke, K. M. Jones, B. F. Moon, C. M. Howison, and M. D. Pagel, "Evaluations of Tumor Acidosis Within In Vivo Tumor Models Using Parametric Maps Generated with Acido CEST MRI.", Mol Imaging Biol, vol. 17, issue 4, pp. 488-96, 2015 Aug. PMID: 25622809
Type of Publication: Journal Article

2014

Yoo, B., V. R. Sheth, C. M. Howison, M. J. K. Douglas, C. T. Pineda, E. A. Maine, A. F. Baker, and M. D. Pagel, "Detection of in vivo enzyme activity with CatalyCEST MRI.", Magn Reson Med, vol. 71, issue 3, pp. 1221-30, 2014 Mar. PMCID: PMC3742626  PMID: 23640714
Type of Publication: Journal Article
Lee, J., J. Cárdenas-Rodríguez, M. D. Pagel, S. Platt, M. Kent, and Q. Zhao, "Comparison of analytical and numerical analysis of the reference region model for DCE-MRI.", Magn Reson Imaging, vol. 32, issue 7, pp. 845-53, 2014 Sep.
Type of Publication: Journal Article

2013

Cárdenas-Rodríguez, J., C. M. Howison, and M. D. Pagel, "A linear algorithm of the reference region model for DCE-MRI is robust and relaxes requirements for temporal resolution.", Magn Reson Imaging, vol. 31, issue 4, pp. 497-507, 2013 May. PMCID: PMC3639320  PMID: 23228309
Type of Publication: Journal Article
Cárdenas-Rodríguez, J., C. M. Howison, T. O. Matsunaga, and M. D. Pagel, "A reference agent model for DCE MRI can be used to quantify the relative vascular permeability of two MRI contrast agents.", Magn Reson Imaging, vol. 31, issue 6, pp. 900-10, 2013 Jul. PMCID: PMC3721191  PMID: 23583323
Type of Publication: Journal Article

2012

Cárdenas-Rodríguez, J., Y. Li, J-P. Galons, H. Cornnell, R. J. Gillies, M. D. Pagel, and A. F. Baker, "Imaging biomarkers to monitor response to the hypoxia-activated prodrug TH-302 in the MiaPaCa2 flank xenograft model.", Magn Reson Imaging, vol. 30, issue 7, pp. 1002-9, 2012 Sep. PMCID: PMC3402593  PMID: 22554971
Type of Publication: Journal Article

2009

M Ali, M., G. Liu, T. Shah, C. A. Flask, and M. D. Pagel, "Using two chemical exchange saturation transfer magnetic resonance imaging contrast agents for molecular imaging studies.", Acc Chem Res, vol. 42, issue 7, pp. 915-24, 2009 Jul 21.
Type of Publication: Journal Article

2006

Yoo, B., and M. D. Pagel, "A PARACEST MRI contrast agent to detect enzyme activity.", J Am Chem Soc, vol. 128, issue 43, pp. 14032-3, 2006 Nov 1. PMID: 17061878
Type of Publication: Journal Article